I.29 Pituitary adenoma

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PI.29.e1 Basophilic and anaplastic pituitary adenoma (PAS x100). The basophilic cells are also PAS-positive. Basophilic adenomas secrete ACTH, more rarely TSH or sometimes a gonadotropic hormone (FSH or LH). Note the presence of large or pleomorphic nuclei and especially the numerous mitoses indicative of rapid growth (anaplastic adenoma).